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The pathogenesis of PCOS involves oxidative stress as a fundamental factor which disrupts follicular development while inducing granulosa cell apoptosis and promoting insulin resistance ( Nrf2 is a master transcription factor that plays a key role in regulating the expression of antioxidant proteins that protect the body from oxidative damage and inflammation

Prolonged exposure to light, elevated temperature, or aqueous environments may reduce stability

After the age of 40, declining progesterone levels lead to a fall in testosterone levels