The leptin-melanocortin axis, the opioid system, glucagon-like peptide-1 (GLP-1)/glucagon-like peptide-1 receptor (GLP-1R) system, and fibroblast growth factor 21 (FGF21)/its receptor complex FGFR1c/-klotho axis are several common pathways confirmed by researches and pharmacological targets that play an essential role in regulating energy balance and feeding behavior (2)
The most common side effects reported by patients are mild to moderate gastrointestinal symptoms, such as nausea, vomiting, diarrhea, and constipation
[11] Tirzepatide is a prescription medication approved by the FDA for the treatment of type 2 diabetes (under the brand name Mounjaro) and chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity (under the brand name Zepbound)
8 Over time, elevated blood sugar levels can result in a range of health complications affecting multiple organ systems, including the heart, kidneys, feet, and retina
