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It was impressive to see that every dose of retatrutide resulted in clinically meaningful weight reduction for nearly all participants, and people with severe obesity on the highest dose lost an average of 30% of their body weight over two years, said Ania Jastreboff, the lead investigator of the study, in a press release

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Key drug interactions with methotrexate include: Non-steroidal anti-inflammatory drugs (NSAIDs) may increase methotrexate levels, though many can be used with caution at low-dose methotrexate with appropriate monitoring Trimethoprim and co-trimoxazole are contraindicated due to increased folate antagonism Proton pump inhibitors may affect methotrexate levels, particularly with high-dose methotrexate regimens Certain antibiotics, particularly penicillins, that can reduce renal clearance Patients taking methotrexate require regular blood monitoring, including full blood count, liver function, and renal function

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