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While some trials show no major changes in BMD, others suggest slight improvements in bone turnover markers: Trials of liraglutide and exenatide generally show stable BMD over 612 months Certain populations such as postmenopausal women or individuals with rapid weight loss may show changes in bone markers like osteocalcin and P1NP However, most of these studies are small, short-term, or not powered for skeletal endpoints

First synthesized in the 1990s, MT-2 is classified as a non-selective melanocortin receptor agonist, meaning it is structurally compatible with multiple receptor subtypes (MC1R, MC3R, MC4R, MC5R)

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