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Several potential mechanisms could theoretically link semaglutide to back pain, though these remain speculative and lack substantial clinical evidence: Pancreatitis : Acute pancreatitis, a recognized rare complication of GLP-1 agonists, typically presents with epigastric pain radiating to the mid-back rather than the lower lumbar region

Glutaminases catalyze glutaminolysis in mitochondria, regulating oxidative phosphorylation, redox status and cell metabolism for tumour growth

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