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Diabetologia 58:604614 Finan B, Clemmensen C, Zhu Z et al (2016) Chemical hybridization of glucagon and thyroid hormone optimizes therapeutic impact for metabolic disease

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A reduction in the levels of GSH, and consequently of antioxidant defenses, may increase the risk of damage to the host via transcription factor activation leading to up-regulation of proinflammatory cytokines, such as nuclear transcription factors and activator proteins, induced in turn by agents such as hydrogen peroxide, mitogens, bacteria, viruses, and UV and ionizing radiation