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Fatty Liver Disease Individuals with non-alcoholic fatty liver disease (NAFLD) may particularly benefit from retatrutide's glucagon-mediated hepatic fat reduction, which showed up to 81% liver fat reduction in trials

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Typically, about 75 percent of weight loss comes from fat, with roughly 25 percent coming from fat-free mass, says Sriram Machineni, MD, an endocrinology, diabetes, and metabolism expert at Montefiore Health System in New York City

This leads to an advance stage of atherogenesis in which plaques contain lipids, cholesterol, macrophages and altered myocytes 5