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In conclusion, there seems to exist a p53/MDM2/IGF-1R axis, in which signals are propagated in either direction

The global prevalence of diabetes continues to rise, with projections indicating a substantial increase in disease burden over the coming decades ( Patients with T2DM and ESRD represent a particularly high-risk population characterized by advanced metabolic dysfunction, a high burden of cardiovascular disease, and extensive polypharmacy ( Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) improve glycemic control by increasing glucose-dependent insulin secretion, suppressing glucagon release, delaying gastric emptying, and inducing weight loss

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