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The unfolded protein response within ER activate the PERK-NRF2 axis, inducing antioxidant gene expression to alleviate oxidative stress [143]

To validate these findings, we examined the protein levels of key NOTCH pathway components (HEY1, HES1, and NOTCH1) by Western blot in LUAD cells with SLC25 A39 knockout (koSLC25 A39) and overexpression (oeSLC25A39)

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We understand that hospitals may not know plan design, payer-based algorithms, or patient acuity, that are determined after the episode of care is complete, and also understand that an MRF in JSON or CSV that captures standard charge information at the item or service level cannot possibly account for every patient scenario