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doi: 10.1038/nrrheum.2011.207 Summary Keywords gout, bile acid metabolism, uric acid homeostasis, NLRP3 inflammasome, gut-joint axis, FXR antagonists Citation Sun H, Yang L, Sun Y, Zhang X, Sun X, Zhao X, Sun H, Zhang Q, Yan G and Wang X (2025) Dysregulated bile acid metabolism as a novel player in gout progression: emerging therapeutic strategies

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Although the conclusions from this study are limited to neuronal cells in vitro, the mechanism of selective splicing of SS4 by neurexins in a physiological setting needs to be investigated by experiments that truly mimic neuronal activity to clarify its biological significance [81]