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The action of these systems determines the overall endogenous antioxidant capacity, and if this capacity is exceeded, oxidative stress ensues, potentially resulting in detrimental oxidation of cell membranes, functional proteins, and DNA [911]

[DOI] [PMC free article] [PubMed] [Google Scholar] Reddy IA, Pino JA, Weikop P, Osses N, Srensen G, Bering T, Valle C, Bluett RJ, Erreger K, Wortwein G, Reyes JG, Graham D, Stanwood GD, Hackett TA, Patel S, Fink-Jensen A, Torres GE, Galli A, 2016

This is linked to the GIP pathway: Insulin release that depends on glucose Keeping metabolic signals in check Having an effect on the function of pancreatic beta cells The GLP-1 pathway helps with the following: Sugar control Controlling your appetite Changes in how the stomach empties Tirzepatide works differently from other GLP-1 receptor agonists because it combines both routes into a single chemical structure

Salat D, Noyce AJ, Schrag A, Tolosa E