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Key administration details for compounded tirzepatide: Subcutaneous injection, once weekly Rotate injection sites: abdomen, thigh, upper arm Store reconstituted solution in refrigerator Refrigeration is required after reconstitution Shelf life in fridge : typically 28-30 days after reconstitution Room temperature stability is limited, see tirzepatide room temperature guidelines Retatrutide administration Retatrutide is currently available only as a research compound in lyophilized powder form

Noom members on GLP-1s actually log more meals, weigh in more often, and log more exercise by their second month than those on Noom without a GLP-1

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Parallel 26-week GLP repeat-dose studies in SpragueDawley rats were conducted under comparable conditions and are described in the Supplementary Methods