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In some embodiments, the otoprotectant is a compound of Formula (V): wherein: R 1 is C 6 -C 10 aryl or C 3 -C 9 heteroaryl, wherein C 6 -C 10 aryl and C 3 -C 9 heteroaryl are optionally substituted with one or more R 4

While studies havent fully elucidated exactly how Botox mitigates scars, he says, its thought to work, at least in part, by minimizing movement around incisions to prevent pulling

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For patients with type 2 diabetes, dose advancement is considered when hemoglobin A1c remains above target (typically 7% for most adults, though individualized based on patient factors) or when fasting and postprandial glucose levels exceed goals