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[DOI] [PMC free article] [PubMed] [Google Scholar] 316.Roumeliotis S., Dounousi E., Eleftheriadis T., Liakopoulos V

186,187,509,510 The accumulated DNA oxidative damage in AD hyper-activates the DNA damage sensor PARP-1, thereby reducing the concentration of cellular NAD + and suppressing the function of NAD + -SIRT1-PGC-1 axis, which in turn causes abnormal mitochondria