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Persistently elevated prolactin was demonstrated by large studies to increase the all-cause mortality, emphasizing the need for treating this condition promptly (95, 96)

This multi-agonist strategy has potential to become the most effective pharmacological approach to reversing obesity and related metabolic disorders [32, 25]

Overall, the computational framework presented here offers a robust and generalizable blueprint for the rational discovery of incretin mimetics

However, the results of these two studies contrast with our study, possibly because they included only two studies and one study of semaglutide, whereas other GLP-1 receptor agonists may have different effects on these outcomes