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Recent studies showed that omentin-1 could protect NP cells from ongoing senescence, inflammation, apoptosis, or matrix metabolism imbalance in the presence of IL-1 through activating SIRT1 or the phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB, also known as Akt) signaling pathway (49)

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Methods Preparations The experimental protocols were approved by the Institutional Animal Care and Use Committee of Showa University (approval no