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Fibroblast growth factor-21 improves pancreatic beta-cell function and survivalby activation signal-regulated kinase 1/2 and Akt signaling pathways

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Impaired neuro-progression, which results in somatic symptoms including anhedonia, anxious behavior, fatigue, discomfort, and psychiatric symptoms such as mild cognitive impairment (MCI), is associated with the progression of depression (71, 72)

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That is the highest weight loss ever recorded for any drug (Lilly Press Release, Dec 2025)

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Clinical parameters of each group of the DKD rats were shown in Table 1

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