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Senescent chondrocytes accumulate in osteoarthritic joints, contributing to inflammation and tissue breakdown via the senescence-associated secretory phenotype (SASP)

In a third step, CoQH2 bound to LDHB and NAD+ undergoes aerobic auto-oxidation to CoQ, as previously shown for PQQH2 bound to LDH(A), in the presence of NAD+ 48 completing the cycle and resulting in NAD+ and CoQ bound to LDHB

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