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Seek medical advice if cramps are severe, persistent, or accompanied by swelling, redness, weakness, or other concerning symptoms such as chest pain or breathlessness

Rag2 / Il2rg double-knockout mice purchased from The Jackson Laboratory (stock 014593) were back crossed onto the BALB/c genetic background for 8+ generations, with WT littermates used as controls

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Regarding cardiovascular and renal effects, the two drug classes appear to work additively: SGLT2is primarily exert their cardiovascular benefits through hemodynamic effects, while GLP-1RAs mainly work through anti-atherogenic and anti-inflammatory actions 26