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Second, YPEL5 shows striking structural homology to the thalidomide-binding domain of CRBN (CRBN CTD ), raising a question whether BRD4ZZ1 binding occurs through a similar structural mechanism

The compound was developed by the Australian biotech firm Metabolic Pharmaceuticals as a research tool to isolate the lipolytic signaling domain of growth hormone without the receptor-binding region responsible for its anabolic and glucose-handling effects

Indeed, fecal samples from MS patients, when transplanted into germ-free mice, can exacerbate autoimmune encephalitis, whereas feces from healthy donors are less pathogenic [69]

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