10.1126/scisignal.aay5686 Summary Keywords blood-brain barrier, permeability, stroke, hemorrhagic transformation, pathophysiology Citation Bernardo-Castro S, Sousa JA, Brs A, Ceclia C, Rodrigues B, Almendra L, Machado C, Santo G, Silva F, Ferreira L, Santana I and Sargento-Freitas J (2020) Pathophysiology of BloodBrain Barrier Permeability Throughout the Different Stages of Ischemic Stroke and Its Implication on Hemorrhagic Transformation and Recovery
Second, the development of new drugs requires additional and more detailed preclinical and clinical studies to determine whether long-term use is biotoxic, whether the drug has adverse effects on other peripheral organs or whether the drug candidate has a real therapeutic effect on the patients
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