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Common, usually mild: Injection-site reactions (redness, swelling, itching), most frequent with both Mild headache, dizziness, or flushing after injection Initial water retention as IGF-1 rises Transient fatigue in the first 12 weeks Less common, dose-dependent: Carpal tunnel-like wrist symptoms (sign IGF-1 may be too high) Joint discomfort or stiffness Numbness or tingling in extremities Elevated blood glucose (GH antagonizes insulin) The monitoring that matters:IGF-1 (insulin-like growth factor 1, the downstream marker of GH activity) is the lab value that tells you whether youre in a therapeutic range or pushing past it

Daily heart palpitations can be normal if theyre occasional and triggered by common factors like stress, caffeine, hormonal changes, exercise, or dehydration

Oral rehydration solutions, herbal teas like ginger or peppermint, and clear broths are often recommended by healthcare professionals

Additionally, it will be important to study in increasing detail how novel MASH drugs impact not only the molecular pathways involved but also the cellular bases of MASH [34]