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How safety data affects the approval timeline The dysesthesia signal will not necessarily prevent approval, but it will shape the labeling and potentially the approved dose range

CKD benefits were similar, with the FLOW trial (3,500 patients with T2D and chronic kidney disease), Semaglutide (1 mg weekly) reduced the risk of kidney failure events and death from kidney- or cardiovascular-related causes by 24% (HR 0.76

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Injured hepatocytes release Pathogen-Associated Molecular Patterns (PAMPs) and Damage-Associated Molecular Patterns (DAMPs) activate immune responses and recruit Kupffer cells, HSCs, and other immune cells to promote inflammation and fibrosis through cytokine signaling