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In recent years, GLP-1RAs have become well-established therapies in T2DM

Scientists have now discovered that GLP-1 receptors are also present in several parts of the brain involved in mood, memory, reward, and emotion

Semaglutide, sold under the brand names Ozempic, Wegovy and Rybelsus, is an antidiabetic medication used for the treatment of type 2 diabetes and an anti-obesity medication used for long-term weight management, developed by Novo Nordisk in 2012

The conserved disulfide bridge and the added N-terminal tyrosine are hypothesized to support peptide stability and bioavailability, possibly offering resistance to harsh pH conditions and enzymatic degradation