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Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression

Questions persist about bioavailability, tissue penetration, duration of effect, and whether benefits observed in cell and animal models translate reliably to human skin, joints, or systemic health

Studies have described that flavonols and their derivatives are likely the substrate for GSTLs, which tightly bind to these small molecules ( Arabidopsis and wheat Lambda class GSTs ( AtGSTL1, TaGSTL1 , and TaGSTL3) have been identified to be localized in cytosol, whereas others ( AtGSTL2 and TaGSTL2) are chloroplast localized (Theodoulou et al., 2003)

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