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Allosteric regulation has long been recognized for other NRs [77, 81] and has become more apparent and accepted as a mode of regulation for AR activity over the past decade, based on literature reports as those described above

In fact, the inter-relationship of AT1Rs to the intrarenal ANG II content is based on a feed-forward mechanism by which ATR1 binding mediates ANG II intracellular accumulation ( The reasons for elevated renal ANG II levels have been debated for years

However, the peptide had minimal side effects in mice.

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