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The mechanism that links lipogenesis with phagocytosis was later elucidated by Lee et al., who showed that phagocytosis was impaired in LPS-activated Ms isolated from mice deficient in sterol regulatory element binding protein 1a (SREBP-1a) (19), which regulates the transcription of genes related to lipogenesis (20)

De La Torre, R., Casado, A., Lpez-Fernndez, E., Carrascosa, D., Ramirez, V

Zu den betroffenen spezifischen Signalwegen gehren die TGF-Beta-Superfamilie-Signalwege, Wnt-Signalwege, antioxidative Abwehr (einschlielich Superoxiddismutase, Glutathion-S-Transferasen und Thioredoxinreduktase) sowie DNA-Reparaturmechanismen

Existing drugs such as GC therapy, which upregulates CD163, anti-diabetic drug, pioglitazone, which upregulates CD36, and a kinase inhibitor, imatinib, which upregulates SRBI, may be evaluated for potential in regulating the clearance of hemolysis products at the receptor level (Schaer et al., 2002