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With respect to hypertension, several in vivo studies have provided evidence that eNOS uncoupling occurs in animal models of increased blood pressure, including ATII hypertension, 14 DOCA-salt induced hypertension, 57 NOX1 upregulation 83 and genetically determined hypertension 84 in which an uncoupled eNOS was consistently identified as a significant superoxide source

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Interestingly, the study also noted that the function of certain immune cells improved alongside these rising levels

Thus, the lower expression of PKLR and PFK-1 suggest that the ibuprofen affects metabolism and altered hepatic glucose metabolism in male mice