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Medically reviewed by Missy Zammichieli, DNP, APRN, FNP-BC Updated March 26, 2026 HEAD-TO-HEAD HOW THEY WORK (AND WHY IT MATTERS) Both medications mimic gut hormones that your body produces naturally after eating

Vitamin B12 shots may help reduce the risk of serious conditions such as heart disease and stroke as well as cognitive issues, infertility, and neural tube defects (when mothers have B12 deficiency)

Patients with endometriosis have decreased quality and quantity of oocytes and embryos, decreased implantation and pregnancy rates, and increased rates of spontaneous abortion Patients suffered from endometriosis showed lower ovarian reserved (30)

All in all, B12 shots are both safe and efficacious