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GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a copper-binding tripeptide first isolated from human plasma, studied in preclinical models for its effects on gene expression, extracellular matrix remodeling, and oxidative-stress biology

Since redox processes in the cell are highly regulated, the presence of glutathione in the periplasm at such high levels strongly indicates that this molecule also plays a role in the redox homeostasis of the periplasm, similar to its role in the ER (Birk et al., 2013

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