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A recent study in mouse and human hepatocellular carcinoma identified a population of TAM and a population of tumor endothelial cells, FOLR2 + macrophages and PLVAP + endothelial cells respectively, that resembled fetal characteristics (72)

[183] Healthcare providers should monitor patients closely during the discontinuation process and may need to adjust the tapering schedule based on patient response

Another proposed mechanism involves competing interactions at growth factor receptor sites