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Coenzyme Q10 Improves Seminal Oxidative Defense But Does Not Affect on Semen Parameters in Idiopathic Oligoasthenoteratozoospermia: A Randomized Double-Blind, Placebo Controlled Trial

Together, these processes illustrate that fibroblast activation and ECM remodeling are not merely secondary consequences of inflammation but are fundamental drivers of tophus maturation, structural stability, and long-term disease progression, highlighting them as critical therapeutic targets in chronic gout

Tumors derived growth factors like TGF- and platelet-derived growth factor (PDGF) activates the fibroblasts present within the CAFs, which in turn release abundant ECM proteins, leading to desmoplasia with abundant collagen I/III, fibronectin, and other fibrillar matrices (110)