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Description

The overexpression of ACSL4 promotes the catalysis of various PUFAs, alters the cellular lipid composition, and ultimately increases the susceptibility of cells to ferroptosis (Cui et al., 2021)

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Complementing these targeted analyses, a recent epigenome-wide association study demonstrated sex-specific DNA methylation changes and epigenetic age acceleration, including the differential methylation in both CRY2 and RORA, linking NSW to epigenetic alterations in circadian regulators 33

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