Overall, the onset of GI AEs is slightly higher in those trials designed to assess the efficacy and safety of GLP-1 RAs in people with obesity, which may be ascribed to the fact that doses are higher than those used in clinical trials in people with T2D
Multivariate analysis To identify microbiota composition differences between individuals split in TMAO clusters we performed multivariate homogeneity analysis of BrayCurtis dissimilarity matrices at the species level (699 species present in at least 20% of our population) and determined statistical significance with a permutation ANOVA test (999 iterations) using the vegan (v2.5.7) package
[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Kounatidis D., Vallianou N.G., Karampela I., Rebelos E., Kouveletsou M., Dalopoulos V., Koufopoulos P., Diakoumopoulou E., Tentolouris N., Dalamaga M
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