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Combining semaglutide (a GLP-1 receptor agonist) with phentermine (a sympathomimetic) is not FDA-approved as a formal combination, but some providers explore this approach off-label based on differing mechanisms of action

Neither participants nor clinical staff knew which treatment each person received until the study concluded, eliminating potential bias in reporting

Potential Side Effects and Considerations As with any treatment, PT-141 may have side effects, including nausea, flushing, or mild headaches

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