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Not only that, a novel immunogold nanoparticle AuNP@B16F10 developed through intracellular generation and excretion by tumor cells is further internalized by DCs and secreted as DC-derived vesicles, in which the introduction of DC2.4 allows it to enhance T cell proliferation through indirect mediation of APC and direct interaction with T cells, and the infiltration of CD4 + T cells and CD8 + T cells increased after AuNP@DCB16F10 combined with NIR, which further inhibited or even eliminated the primary tumor, metastatic tumor and tumor recurrence, and ultimately improved the overall survival rate of mouse (184)