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In a published Phase 2 trial (48 weeks), adults with obesity who took retatrutide lost, on average, more weight at higher doses, with the 12 mg group showing 24.2% average weight change at 48 weeks (compared with 2.1% in the placebo group)

The molecule was designed to be stable in the bloodstream for a full week, so each administration covers seven days of receptor activity from a single subcutaneous injection

Lastly, if a patient is already experiencing damage to his or her eyes due to high blood sugar (called diabetic retinopathy), one should consult with their eye doctor before starting a GLP-1, especially semaglutide

While large-scale studies are still ongoing, initial research has shown encouraging results: Direct Anti-Inflammatory Action: These drugs can reduce inflammation independently of weight loss by blocking specific cellular pathways