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In goblet cells, elevated MUC2 mucin expression and misfolding lead to ER stress, triggering reactive oxygen species production and apoptosis, ultimately disrupting the integrity of the mucus barrier [90]

American Journal of Clinical Nutrition, 115(4), 787-789

HAT expression has also been found to be increased four-fold in whole blood RNA from untreated PLWH compared to seronegative individuals (Marimani et al., 2020)

This study demonstrates how LCMS/MS platformssuch as those offered by Creative Proteomicsenable accurate metabolite quantification and support metabolic biomarker validation