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These findings suggest that research into the therapeutic modulation of FOXO4 activity, such as through the use of the synthetic peptide FOXO4-DRI, could provide insight into the heart's natural protective mechanisms and degenerative changes associated with aging

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(7.5 MB EPS) Acknowledgments Schistosome life stages used in this research were supplied in part by the National Institute of Allergy and Infectious Diseases (NIAID) Schistosomiasis Resource Center at the Biomedical Research Institute (Rockville, Maryland, United States) through NIAID Contract NO1-AI-30026

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