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Rare adverse effects included gallbladder-related issues (mostly gallstones) in 2.6% of the semaglutide group versus 1.2% with placebo, with pancreatitis reported in 0.2% with semaglutide versus 0% with placebo.18 In an RCT of 2539 adults with BMI 30, or BMI 27 with at least 1 weight-related complication, but without diabetes, participants were randomly assigned to receive tirzepatide 5 mg, 10 mg, 15 mg, or placebo weekly for 72 weeks, in addition to health behaviour changes

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