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The American Diabetes Association (ADA) guidelines recommend GLP-1 receptor agonists as preferred agents for patients with type 2 diabetes who have established atherosclerotic cardiovascular disease or indicators of high cardiovascular risk, or for those requiring additional glucose-lowering beyond metformin
GLP-1 agonists, by contrast, activate G-protein coupled receptors on pancreatic beta cells and intestinal L-cells, slowing gastric emptying and promoting satiety
According to comprehensive weight loss plateau GLP-1 research, about one-third of non-diabetic patients on GLP-1s achieve 10% weight loss, but progress typically stalls after 2024 weeks
When you lose weight, youre going to lose lean muscle mass
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