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A person-centered trial design including individuals with inadequate metabolic response to subcutaneous semaglutide 2 mg once weekly, but who tolerate the dose well, could be used to more precisely assess whether higher doses are beneficial for such a subpopulation

For example, researchers demonstrated that liraglutide improves atrial inflammatory signaling in heart attack mouse models, revealing a possible mechanism for its role in reducing cardiovascular disease risks in patients with type 2 diabetes

PlexusDx patients interested in optimizing their response can explore the Precision Peptide Genetic Test, which maps 14 pathways and 49 peptides to reveal individual variations in GLP-1 receptor sensitivity and related metabolic factors