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The concentration of CP in serum is 300450 g/mL and CP in cerebrospinal fluid is only 1 g/ mL 39 , and increased CP in different brain regions has been observed in NDs 40 , therefore, the role of CP in brain and its relationship with PD might be different

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However, with respect to desensitization, D 3 R but neither D 2 R nor D 4 R, develops desensitization [23, 24], suggesting that different mechanisms could be involved in the desensitization of GPCRs, depending on receptor or cell environment characteristics