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This study showed a mean weight reduction of 10%, and significant reductions in triglyceride, total cholesterol, and LDL-C levels of 25%, 11%, and 11% respectively [32]

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doi: 10.1016/S1134-3230(10)64003-3

Tirzepatide options typically hit harder initially, with more patients reporting vomiting or diarrhea in early weeks, while semaglutide-based drugs tend to cause nausea that tapers off as the body adjusts