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Understanding these physiological mechanisms helps patients distinguish between benign colour variations and those requiring medical assessment

a study assessing the response to 5-AMP-activated protein kinase (AMPK) activators (5-aminoimidazole-4-carboxamide ribonucleotide [AICAR] and metformin) suggests GLUT2 localisation to the apical membrane is mediated via rapid AMPK phosphorylation [38, 39]