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The overall risk of gallstone formation is comparable across these medications

If a DPP-4 inhibitor is contraindicated, not tolerated or not effective, consider: pioglitazone or an insulin-based treatment (7) Adults with frailty For adults with type 2 diabetes and frailty: modified-release metformin should be offered an SGLT2 inhibitor should only be offered if the person's level of frailty does not place them at risk of adverse events from such a medicine (for example, volume depletion or hypotension) If metformin is contraindicated or not tolerated, assess whether their level of frailty places the person at risk of adverse events from SGLT-2 inhibitors: if it does not, consider monotherapy with a SGLT-2 inhibitor if it does, consider monotherapy with a DPP-4 inhibitor Introducing medicines in a stepwise manner Medicines should be introduced in a stepwise manner, checking for tolerability and effectiveness of each medicine

Accessed via Glucagon-like peptide 1 (GLP-1)

Pricing remains fixed regardless of medications you're taking