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As patients lose weight, blood pressure often naturally decreases, creating a paradoxical benefit: while semaglutide itself may cause mild blood pressure elevation in some individuals during early weeks, the subsequent weight loss typically produces a net reduction in systolic and diastolic readings

By adopting a dual-pathway strategytargeting both pain relief and inflammation reductionwe observed significant improvements in joint function during clinical trials involving over 5,000 participants

(Ali et al

Semaglutide acts primarily via GLP-1 receptors in the gut and brain, reducing appetite largely through GLP-1 receptor-mediated pathways