According to the lawsuit, the companies failed to adequately warn healthcare providers and patients about the potential risks associated with these drugs, despite evidence and reports of gastrointestinal issues dating back to 2010
In addition, the Department of Mental Health and Substance Abuse Services asked for $11.5 million to pay addiction treatment providers more and $4 million to assist in retaining staff for the behavioral health safety net program
Common suspects include large fatty meals, eggs, meat, onions, garlic, cruciferous vegetables, legumes, dairy, sugar alcohols, beer, and carbonation
Notably, LEO downregulated ACADM , NDUFB8 , SOD2 , COX4I1 , and SDHB (involved in fatty acid oxidation and ROS detoxification), while concurrently upregulating IDH3A , GPX1, CPT1A, PDK4, and MPC1/2 (critical for TCA cycle flux and pyruvate metabolism)