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Cao et al (174) demonstrated that Ex-4 reduced lipid accumulation and insulin resistance in the skeletal muscle of obese mice induced by a high-fat diet by activating AMPK and upregulating insulin signaling pathways

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Chronic Granulomatous Disease Because of the need for NADPH in phagocytic cells, by the NADPH oxidase (NOX) system, any defect in enzymes in this process can result in impaired killing of infectious organisms