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The EMPA-KIDNEY trial enrolled a larger proportion of participants without diabetes mellitus and included individuals with lower mean eGFR (37.3 mL/min/1.73 m) and median UACR (329 mg/g) compared to DAPA-CKD

By modulating the release of dopamine, the medication may make sweet foods feel less rewarding. If the brain no longer receives a massive surge of pleasure from a sugary snack, the motivation to seek out that snack begins to fade

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